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Fibromyalgia is a chronic and painful musculoskeletal disorder. However, co-administration of duloxetine (60 or 120 mg) with warfarin (2-9 mg a highly protein-bound drug, did not result in significant changes name in INR and in the pharmacokinetics of either total S-or total R-warfarin (protein bound plus free drug) see brand drug interactions. Postmarketing reports of hepatic injury (including hepatitis and cholestatic jaundice) suggest that patients with preexisting liver disease who take duloxetine may have an increased risk for further liver damage. This can name increase your risk of liver damage which can cause a permanent disorder in the body. Discontinuing cymbalta Adverse reactions after discontinuation of cymbalta, after abrupt or tapered discontinuation, include: dizziness, headache, nausea, diarrhea, paresthesia, irritability, vomiting, insomnia, anxiety, hyperhidrosis, and fatigue. Duloxetine is usually taken 1 or 2 times per day with or without food. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Pay close attention to any changes in mood, behavior, actions, thoughts, brand or feelings, especially sudden changes. The fixed-dose study evaluated cymbalta doses of 60 mg once daily (N168) and 120 mg once daily (N170) compared to placebo (N175) over a 9week treatment period. Are there Alternative Names for the Brand and Generic Cymbalta? Do not double your next dose or take more than what is prescribed. Talk to your doctor about other drug options that may work for you. Symptoms of an overdose of this drug can include: tiredness seizures dizziness increased heart rate high blood pressure vomiting If you think youve taken too much of this drug, call your doctor or seek guidance from the American Association. There is no sufficient evidence regarding whether or not it is safe to use Cymbalta while pregnant or breastfeeding. The most commonly reported symptoms following discontinuation of cymbalta in pediatric clinical trials have included headache, dizziness, insomnia, and abdominal pain see warnings name AND precautions and Adverse Reactions Reported As Reasons For Discontinuation Of Treatment In Adult Placebo-Controlled Trials. Cymbalta can be given without regard to meals. Chronic cymbalta Musculoskeletal Pain: Two 12-to 13-week trials in adult patients with chronic low back pain (clbp) and one 13-week trial in adult patients with chronic pain due to osteoarthritis see Chronic Musculoskeletal Pain. This medication passes into breast milk and may affect the nursing infant. Roughly 1,300 people have filed about 140 lawsuits in various federal and state courts alleging injuries arising from the discontinuation of Cymbalta use. Wong DT, Robertson DW, Bymaster FP, Krushinski JH, Reid. Glycemic Control In Patients With Diabetes As observed in dpnp trials, cymbalta treatment worsens glycemic control in some patients with diabetes. Give patients the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. Hepatic Impairment Avoid use in patients with chronic liver disease or cirrhosis see dosage AND administration, Hepatotoxicity, and Use In Specific Populations. Cymbalta side effects such as liver disease, withdrawal symptoms and low blood pressure. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant name use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged cymbalta 65 and older see warnings AND. It works by balancing chemicals in your brain that cause depression and anxiety. Patients on cymbalta experienced a statistically significantly longer time to relapse of depression than did patients on placebo (Study 5 in Figure 1). Inactive ingredients include FD C Blue. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. CYP2D6 Inhibitors Because CYP2D6 is involved in cymbalta metabolism, concomitant use of cymbalta with potent inhibitors of CYP2D6 would be expected to, and does, result in higher concentrations (on average of 60) of cymbalta see drug interactions. Johns Wort) and with drugs that impair metabolism of serotonin (in particular, maois, name both those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).